Playing in her second Grand Slam with Vandeweghe following the pair's run to last year's US Open semifinals, Hingis struggled with her opening service game and they had to bat away two break points. They struck late in the set, pouncing on Jankovic to grab the lone break to love.
Hingis and Vandeweghe kept up the momentum in the second, with Vandeweghe's powerful serves and booming groundstrokes complementing Hingis' fine net play perfectly. They raced ahead to a double break lead.
Jankovic and Wickmayer tried to hold on, breaking back to climb out of a 5-1 deficit and get up to 5-4, but it wasn't enough against the No.5 seeds who comfortably served out the match for a spot in the second round.