Djokovic and Federer have met in the final the past two years at the All England Club.
Meanwhile, second seed and 2013 champion Andy Murray is on a semi-final collision course with fourth seed Stan Wawrinka.
Federer headlines the second quarter of the draw. The 34-year-old Swiss was forced to miss Roland Garros, ending his Open Era-record streak of 65 straight Grand Slam appearances, but returned on the grass in Stuttgart and Halle with two semi-final showings. Federer, who lifted his seventh Wimbledon trophy in 2012 (d. Murray), opens his campaign against Guido Pella.
The first seed Federer could face is No. 30 Alexander Dolgopolov, with two Frenchmen – No. 16 Gilles Simon and No. 17 Gael Monfils – leading the charge to face the Swiss in the fourth round, though former semi-finalist Grigor Dimitrov also features in that section.